The active ingredient in Serene, DHH-B, is a polyphenolic compound derived from magnolia tree bark that exerts neuroprotective and anxiolytic properties through a variety of mechanisms. Magnolia bark has been traditionally used in medical practices throughout much of southeast Asia and has become widely studied by scientists for its pleiotropic effects. DHH-B may help relieve feelings of anxiousness and may also help inhibit stress-inducing hormones like adrenaline and cortisol. Serene may also help support a healthy body and mind by delivering powerful antioxidant support, which may also help reduce inflammation and oxidative stress.